MT-125 (free base)

• Description:

  MT-125 free base is a specific and well-tolerated inhibitor of non-muscle myosin IIA (Ki, NMIIA = 2.7 μM) and IIB (EC50 = 1.7 μM) . MT-125 free base can pass through the blood-brain barrier. MT-125 free base induces ferroptosis and DNA damage by increasing the levels of reactive oxygen species (ROS) within tumor cells. MT-125 free base can enhance the PDGFR signaling pathway. MT-125 free base can be used for research on glioblastoma[1].

• UNSPSC:

  12352005

• Target:

  Akt; ERK; Ferroptosis; mTOR; Myosin; PDGFR; Reactive Oxygen Species (ROS)

• Related Pathways:

  Apoptosis; Cytoskeleton; Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

• Field of Research:

  Cancer; Inflammation/Immunology

• Purity:

  98.6600

• Smiles:

  CC1=CC2=C(N=C(N(C3=CC4=C(N=C(C)C=C4)C=C3)CC5)[C@]5(O)C2=O)C=C1

• Molecular Formula:

  C22H19N3O2

• Molecular Weight:

  357.41

• References & Citations:

  [1]Kenchappa RS, et al. MT-125 inhibits non-muscle myosin IIA and IIB and prolongs survival in glioblastoma. Cell. 2025 Jun 3:S0092-8674 (25) 00569-0.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  PDGFRα

• CAS Number:

  [2404652-80-6]