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MT-125

CAT: 0804-HY-174406-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-174406-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MT-125 is a specific and well-tolerated inhibitor of non-muscle myosin IIA (Ki, NMIIA = 2.7 μM) and IIB (EC50 = 1.7 μM) . MT-125 can pass through the blood-brain barrier. MT-125 induces ferroptosis and DNA damage by increasing the levels of reactive oxygen species (ROS) within tumor cells. MT-125 can enhance the PDGFR signaling pathway. MT-125 can be used for research on glioblastoma[1].
UNSPSC
12352005
Target
Akt; ERK; Ferroptosis; mTOR; Myosin; PDGFR; Reactive Oxygen Species (ROS)
Related Pathways
Apoptosis; Cytoskeleton; Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Cancer
Smiles
CC1=CC2=C(N=C(N(C3=CC4=C(N=C(C)C=C4)C=C3)CC5)[C@]5(O)C2=O)C=C1.Cl
Molecular Formula
C22H20ClN3O2
Molecular Weight
393.87
References & Citations
[1]Kenchappa RS, et al. MT-125 inhibits non-muscle myosin IIA and IIB and prolongs survival in glioblastoma. Cell. 2025 Jun 3:S0092-8674 (25) 00569-0.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PDGFRα

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Alternative Products

CatalogName
GTR19263640-01MT-125
226857CA 125 (Cancer Antigen 125, Carbohydrate Antigen 125, CA-125) discontinued
226857-HRPCA 125 (Cancer Antigen 125, Carbohydrate Antigen 125, CA-125) (HRP) discontinued
226857-FITCCA 125 (Cancer Antigen 125, Carbohydrate Antigen 125, CA-125) (FITC) discontinued
226857-BiotinCA 125 (Cancer Antigen 125, Carbohydrate Antigen 125, CA-125) (Biotin) discontinued
226857-PECA 125 (Cancer Antigen 125, Carbohydrate Antigen 125, CA-125) (PE) discontinued
226857-APCCA 125 (Cancer Antigen 125, Carbohydrate Antigen 125, CA-125) (APC) discontinued
226857-APCA 125 (Cancer Antigen 125, Carbohydrate Antigen 125, CA-125) (AP) discontinued
553388Cancer Antigen 125 (CA-125)
367315CA 125 (MUC16, Cancer Antigen 125, Carbohydrate Antigen 125)

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