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INNO-220

CAT: 0804-HY-174371-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-174371-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
INNO-220 is an orally active, CRBN-dependent molecular glue degrader targeting CK1α. INNO-220 induces cell cycle arrest at G0/G1 phase and triggers apoptosis by degrading CK1α. INNO-220 disrupts the assembly and function of the CARD11/BCL10/MALT1 complex, thereby inhibiting NF-κB signaling in stimulated T cells and lymphoma cells that harbor an activating mutation in CARD11. INNO-220 provides a new direction for lymphoma research[1].
CAS Number
3032576-92-1
UNSPSC
12352005
Target
Casein Kinase; MALT1; MDM-2/p53; Molecular Glues
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; NF-κB; PROTAC; Stem Cell/Wnt
Field of Research
Cancer
Purity
98.60
Solubility
DMSO : 2.5 mg/mL (ultrasonic)
Smiles
CN1N=CC(C2=CC3=C(C(N(C3)C4CCC(NC4=O)=O)=O)C=C2)=C1C5=CC=CC=C5
Molecular Formula
C23H20N4O3
Molecular Weight
400.43
References & Citations
[1]Shi Feng, et al. A highly selective and orally bioavailable casein kinase 1 alpha degrader through p53 signaling pathway targets B-cell lymphoma cells. Leukemia. 2025 May 27.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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