RP-220

CAT: 0804-HY-P6084Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-P6084Size:1 Each
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Description
RP-220 is a renalase peptide targeting NLRP3. RP220 has anti-inflammatory and anti-apoptotic activities. RP220 inhibits renal tubular epithelial cells apoptosis with alkaline insult by activating MAPK signaling pathway. RP220 significantly inhibits NLRP3 expression and reduces macrophage infiltration and kidney tissue damage in acute kidney injury (AKI) mice model. RP-220 can be uses for systemic lupus erythematosus (SLE) and its complication lupus nephritis (LN) research[1].
CAS Number
[1541177-35-8]
UNSPSC
12352209
Target
Apoptosis; NOD-like Receptor (NLR) ; p38 MAPK
Related Pathways
Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway
Field of Research
Inflammation/Immunology
Purity
98.13
Smiles
O=C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](C(C)C)C(N[C@@H](CO)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC(O)=O)C(N[C@@H](CC(N)=O)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(N)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCC(O)=O)C(N[C@@H](CO)C(N[C@@H](CO)C(N[C@@H](CCC(O)=O)C(N[C@@H]([C@@H](C)CC)C(NCC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CS)N
Molecular Formula
C98H166N30O32S
Molecular Weight
2308.61
References & Citations
[1]Wang L, et al. Application of renalamine related active polypeptide RP220 in preparation of medicine for treating kidney diseases. CN110772634A. 2020-02-11.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
NLRP3

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