MPH-220

• Description:

  MPH-220 is a selective and orally active inhibitor of skeletal muscle myosin-2. MPH-220 enables muscle relaxation. MPH-220 is anti-spastic agent that can be used in the research of spasticity and muscle stiffness[1].

• UNSPSC:

  12352005

• Target:

  Myosin

• Type:

  Reference compound

• Related Pathways:

  Cytoskeleton

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/mph-220.html

• Purity:

  99.25

• Solubility:

  DMSO : 100 mg/mL (ultrasonic; warming)

• Smiles:

  O[C@@]12C (N (C3=CC=C (N4CCOCC4) C=C3) CC2) =NC5=C (C=C (S5) C) C1=O

• Molecular Formula:

  C20H21N3O3S

• Molecular Weight:

  383.46

• References & Citations:

  [1]Gyimesi M, et al. Single Residue Variation in Skeletal Muscle Myosin Enables Direct and Selective Drug Targeting for Spasticity and Muscle Stiffness. Cell. 2020 Oct 15;183 (2) :335-346.e13.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  2649776-79-2