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INNO-220

CAT: 0931-T211026-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T211026-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
3032576-92-1
Target
Casein Kinase, Molecular Glues, MALT, MDM-2/p53
Related Pathways
Immunology/Inflammation, Metabolism, PROTAC, Stem Cells, Apoptosis
Bioactivity
INNO-220 is an orally active, CRBN-dependent molecular glue degrader that targets CK1α. By degrading CK1α, INNO-220 induces cell cycle arrest at the G0/G1 phase and triggers apoptosis (Apoptosis) . It disrupts the assembly and function of the CARD11/BCL10/MALT1 complex, inhibiting the NF-κB signaling pathway in T cells and lymphoma cells with activating mutations in CARD11. INNO-220 offers a novel direction for lymphoma research.
Smiles
O=C1NC(=O)C(N2C(=O)C3=CC=C(C=C3C2)C=4C=NN(C4C=5C=CC=CC5)C)CC1
Molecular Formula
C23H20N4O3
Molecular Weight
400.43
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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