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CMKLR1 antagonist 2

CAT: 0804-HY-174139Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-174139Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CMKLR1 antagonist 2 (compound 16) is a full and competitive chemerin/chemokine-like receptor 1 (CMKLR1) antagonist with an IC50 of 37 μM. CMKLR1 antagonist 2 can be used for study of inflammation[1].
UNSPSC
12352100
Target
CCR
Related Pathways
GPCR/G Protein; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
O=C1C(S(C2=CC=C(C(Cl)=C2)C)(=O)=O)=CNC(SCC(NC3=CC=C(C=C3)C(F)(F)F)=O)=N1
Molecular Formula
C20H15ClF3N3O4S2
Molecular Weight
517.93
References & Citations
[1]Schermeng T, et al. Similar Binding Mode of a 5-Sulfonylthiouracil Derivative Antagonist at Chemerin Receptors CMKLR1 and GPR1. J Med Chem. 2025 Jun 12;68 (11) :11149-11173.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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