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(Rac) -BMS-986449

CAT: 0804-HY-173630ASize: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-173630ASize:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(R) -BMS-986449 is the racemic mixture of BMS-986449 (HY-173630) . BMS-986449 is a CELMoD molecular glue and an IKZF2/IKZF4 degrader. BMS-986449 targets the degradation of transcription factors Helios (IKZF2) and Eos (IKZF4) in regulatory T (Treg) cells. BMS-986449 redirects the E3 ubiquitin ligase Cereblon to induce the degradation of Helios and Eos, reprogramming Treg cells and enhancing antitumor immunity. BMS-986449 is promising for research of advanced solid tumors[1].
UNSPSC
12352005
Target
IKZF Family; Molecular Glues
Related Pathways
Immunology/Inflammation; PROTAC
Field of Research
Cancer
Purity
99.05
Smiles
NC1=NC(C2=C(C(C(N3C4CCC(NC4=O)=O)C)=C(C=C2)C3=O)F)=CC(C)=C1C
Molecular Formula
C21H21FN4O3
Molecular Weight
396.41
References & Citations
[1]Barnes M J. Selective degradation of Helios induces Treg cell reprogramming and enhanced antitumor immunity[J]. Cancer Research, 2025, 85 (8_Supplement_1) : 2249-2249.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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