CC-647

CAT: 0931-T211005-01Size: 10 mgDry Ice: NoHazardous: No

CAT#: T211005-01Size: 10 mg

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PRICE

AVAILABILITY

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

1061605-35-3

Target

E1/E2/E3 Enzyme|||Molecular Glues

Related Pathways

PROTAC|||Ubiquitination

Bioactivity

CC-647 is a molecular glue modulator targeting the Cereblon (CRBN) E3 ubiquitin ligase. It enhances the interaction between CRBN and ZBTB16, as well as its oncogenic fusion protein RAR?-ZBTB16, with a half-maximal degradation concentration (DC50) of 103 nM for ZBTB16. CC-647 holds potential for studying ZBTB16-RAR? related acute promyelocytic leukemia (APL) .

Smiles

O=C1C=2C=CC=C(OC3=CC=CC(=C3)C(C)(C)C)C2C(=O)N1C4C(=O)NC(=O)CC4

Molecular Formula

C23H22N2O5

Molecular Weight

406.43

Shipping Conditions

Cool pack

Storage Temperature

-20°C

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