CC-647

• Target:

  E1/E2/E3 Enzyme|||Molecular Glues

• Related Pathways:

  PROTAC|||Ubiquitination

• Bioactivity:

  CC-647 is a molecular glue modulator targeting the Cereblon (CRBN) E3 ubiquitin ligase. It enhances the interaction between CRBN and ZBTB16, as well as its oncogenic fusion protein RAR?-ZBTB16, with a half-maximal degradation concentration (DC50) of 103 nM for ZBTB16. CC-647 holds potential for studying ZBTB16-RAR? related acute promyelocytic leukemia (APL) .

• Smiles:

  O=C1C=2C=CC=C(OC3=CC=CC(=C3)C(C)(C)C)C2C(=O)N1C4C(=O)NC(=O)CC4

• Molecular Formula:

  C23H22N2O5

• Molecular Weight:

  406.43

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1061605-35-3