TK-684

• Description:

  TK-684 is a potent and selective allosteric SHP2 inhibitor with IC50 values of 2.1, > 1000 nM for SHP2WT, SHP22PTP, respectively. TK-684 inhibits cell proliferation and induces apoptosis. TK-684 decreases the protein expression of p-AKT, p-ERK[1].

• UNSPSC:

  12352005

• Target:

  Apoptosis; SHP2

• Related Pathways:

  Apoptosis; Protein Tyrosine Kinase/RTK

• Field of Research:

  Cancer

• Smiles:

  ClC1=C (N=CC=C1SC2=NNC (N=C (N3) N4CCC (C) (CC4) CN) =C2C3=O) N

• Molecular Formula:

  C17H21ClN8OS

• Molecular Weight:

  420.92

• References & Citations:

  [1]Song Y, et al. Structure-Guided Design of Pyrazolopyrimidinones as Highly Potent and Selective Allosteric SHP2 Inhibitors. J Med Chem. 2025 Apr 16.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported