DPC 684

• Target:

  HIV Protease

• Related Pathways:

  Microbiology/Virology|||Proteases/Proteasome

• Bioactivity:

  DPC 684 is a potent and selective HIV-1 protease inhibitor with an IC90 of 5.7-40 nM and a Ki of 0.021 nM. It competitively inhibits HIV-1 protease, preventing viral polyprotein cleavage. Compared to cellular proteases, DPC 684 shows high selectivity for retroviral proteases. The compound exhibits low protein binding and offers broad-spectrum inhibition against various wild-type and mutant HIV-1 proteases, with an IC90 of 1.9-6.3 nM. DPC 684 is significant for HIV research.

• Smiles:

  [C@@H]([C@@H](CN(S(=O)(=O)C1=CC=C(N)C=C1)CC(C)C)O)(CC2=CC=CC=C2)NC([C@@H](NC(CNCC3=CC(F)=CC=C3)=O)[C@](C)(C)C)=O

• Molecular Formula:

  C35H48FN5O5S

• Molecular Weight:

  669.85

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  284661-73-0