TK-642

TK-642

• CAS Number: 2765183-10-4
• UNSPSC Description: TK-642 is a highly active, selective, orally activity SHP2 inhibitor based on pyrazole and pyrazine (IC50=2.7 nmol/L). TK-642 can effectively inhibit the proliferation of esophageal carcinoma cells and induce cell apoptosis. TK-642 can be used in the study of esophageal cancer[1].
• Target Antigen: SHP2
• Type: Reference compound
• Related Pathways: Protein Tyrosine Kinase/RTK
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/tk-642.html
• Smiles: NCC1(C)CCN(C2=CN=C3C(NN=C3SC4=C(Cl)C=NC=C4)=N2)CC1
• Molecular Weight: 389.91
• References & Citations: [1]Tang K, et al. Discovery of TK-642 as a highly potent, selective, orally bioavailable pyrazolopyrazine-based allosteric SHP2 inhibitor[J]. Acta Pharmaceutica Sinica B, 2024.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported