Products for Research Use Only
RegisterLogin

TK-642

CAT: 0804-HY-158762Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-158762Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
TK-642 is a highly active, selective, orally activity SHP2 inhibitor based on pyrazole and pyrazine (IC50=2.7 nmol/L) . TK-642 can effectively inhibit the proliferation of esophageal carcinoma cells and induce cell apoptosis. TK-642 can be used in the study of esophageal cancer[1].
CAS Number
2765183-10-4
UNSPSC
12352005
Target
SHP2
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tk-642.html
Smiles
NCC1(C)CCN(C2=CN=C3C(NN=C3SC4=C(Cl)C=NC=C4)=N2)CC1
Molecular Formula
C17H20ClN7S
Molecular Weight
389.91
References & Citations
[1]Tang K, et al. Discovery of TK-642 as a highly potent, selective, orally bioavailable pyrazolopyrazine-based allosteric SHP2 inhibitor[J]. Acta Pharmaceutica Sinica B, 2024.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

[1-[3-[(3-chloro-4-pyridinyl)sulfanyl]-1H-pyrazolo[3,4-b]pyrazin-6-yl]-4-methylpiperidin-4-yl]methanamine
CAS Number2765183-10-4
PubChem CID171714381
IUPAC Name[1-[3-[(3-chloro-4-pyridinyl)sulfanyl]-1H-pyrazolo[3,4-b]pyrazin-6-yl]-4-methylpiperidin-4-yl]methanamine
Molecular FormulaC17H20ClN7S
Molecular Weight389.9
XLogP2.5
Topological Polar Surface Area122
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count4
Heavy Atom Count26
Formal Charge0
Complexity476
SMILES
CC1(CCN(CC1)C2=CN=C3C(=N2)NN=C3SC4=C(C=NC=C4)Cl)CN
InChI
InChI=1S/C17H20ClN7S/c1-17(10-19)3-6-25(7-4-17)13-9-21-14-15(22-13)23-24-16(14)26-12-2-5-20-8-11(12)18/h2,5,8-9H,3-4,6-7,10,19H2,1H3,(H,22,23,24)
InChIKey
DLWCPNNOJKLNDF-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of [1-[3-[(3-chloro-4-pyridinyl)sulfanyl]-1H-pyrazolo[3,4-b]pyrazin-6-yl]-4-methylpiperidin-4-yl]methanamine
CAS: 2765183-10-4
CID: 171714381
Formula: C17H20ClN7S
MW: 389.9
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight389.9
XLogP32.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count4
Exact Mass389.1189425
Monoisotopic Mass389.1189425
Topological Polar Surface Area122 Ų
Heavy Atom Count26
Formal Charge0
Complexity476
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
HY-12332-01JW 642
HY-W952695CRBN ligand-642
HY-12332R-01JW 642 (Standard)
HY-169436Lon-TK
HY-173571TK-685
HY-P1079ω-Agatoxin TK
HY-173573TK-684
HY-151483-01TK-129
HY-W008491-01TK-112690
HY-169435-01TK-OH

Alternative Products

CatalogName
GTR19233977-01TK-642
407472CCF-642
GTR19174394-01JW 642
MBS3840041-01JW-642
T26027-01RA 642
A13774-100JW-642 100mg
sc-364714Chromeo™ 642 alkyne
ARC0953TK
A13774-5JW-642 5mg

Popular Products