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P53/TLR2 modulator-1

CAT: 0804-HY-173309Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-173309Size:1 Each
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Description
P53/TLR2 modulator-1 (Compound Z9) is a modulator that targets both the P53 pathway and TLR2 simultaneously, exhibiting anti-radiation activity. P53/TLR2 modulator-1 reduces apoptosis by inhibiting the radiation-induced expression of P53 and Bax. At the same time, it activates the TLR2 pathway, upregulates the expression of downstream proteins MyD88 and P65, and promotes the secretion of cytokines such as IL-6, thus exerting an anti-radiation effect. P53/TLR2 modulator-1 shows significant anti-radiation activity against both AHH-1 cells and HUVECs. It can also increase the survival rate of C57BL/6J mice irradiated with a lethal dose of radiation and reduce the damage to their hematopoietic system, the villous structure of the small intestine, and the spleen caused by radiation. P53/TLR2 modulator-1 can be used in the research of radiation injury-related diseases[1].
UNSPSC
12352005
Target
Apoptosis; Bcl-2 Family; Interleukin Related; MDM-2/p53; MyD88; Toll-like Receptor (TLR)
Related Pathways
Apoptosis; Immunology/Inflammation
Field of Research
Cancer
Smiles
O=S(C1=NC2=CC=CC=C2N=C1)(CC3=CC=C(C#N)C=C3)=O
Molecular Formula
C16H11N3O2S
Molecular Weight
309.34
References & Citations
[1]He Z, et al. Discovery of a novel quinoxaline derivative modulator via a dual P53/TLR2 targeting strategy for the alleviation of radiation damage. Eur J Med Chem. 2025 Jun 5;290:117505.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IL-6; TLR2

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