Products for Research Use Only
RegisterLogin

P53/TLR2 modulator-1

CAT: 0013-GTR19258991-01Size: 50 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19258991-01Size:50 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
P53/TLR2 modulator-1 (Compound Z9) is an agent that targets both the P53 pathway and TLR2, exhibiting radioprotective properties. It mitigates apoptosis by inhibiting radiation-induced expression of P53 and Bax. Concurrently, it enhances the TLR2 pathway by upregulating downstream proteins MyD88 and P65, which promotes secretion of cytokines like IL-6, providing radioprotective effects. P53/TLR2 modulator-1 shows significant radioprotective activity in AHH-1 and HUVECs cells, enhances survival rates in C57BL/6J mice exposed to lethal radiation doses, and alleviates radiation-induced damage to their hematopoietic system, intestinal villi, and spleen. It is applicable for research on radiation-related diseases.
Field of Research
Cancer Biology; Immunology & Inflammation, Cell Biology, Immunology & Inflammation
Storage Conditions
-20°C
Notes
For research use only.

Related Products

CatalogName
GTR19185301-01Mutant p53 modulator-1
GTR19275024-01P53 DUBTAC modulator-1
GTR18846756-01Rat p53 Upregulated Modulator Of Apoptosis (PUMA) ELISA Kit
GTR18858156-01Rat P53 Upregulated Modulator of Apoptosis (PUMA) ELISA Kit
GTR19238450-01TLR2 agonist 1
GTR19264339-01TLR2 antagonist-1
GTR18808772-01Human p53 Upregulated Modulator of Apoptosis (PUMA) ELISA Kit
GTR18846758-01Human p53 Upregulated Modulator Of Apoptosis (PUMA) ELISA Kit
GTR18811728-01Rat p53 Upregulated Modulator of Apoptosis (PUMA) ELISA Kit
GTR18870967-01Rat p53 Upregulated Modulator Of Apoptosis (PUMA) ELISA Kit

Alternative Products

CatalogName
HY-173309P53/TLR2 modulator-1
MBS5806742Mutant p53 modulator-1
HY-176916Mutant p53 modulator-2
137484Puma (p53 Upregulated Modulator of Apoptosis)
145113PUMA (JFY-1, p53 up-regulated modulator of apoptosis)
GWB-D0A9ECAnti-PUMA (p53 Upregulated Modulator of Apoptosis)
301458-PEPUMA (p53 Upregulated Modulator of Apoptosis) (PE)
301458-FITCPUMA (p53 Upregulated Modulator of Apoptosis) (FITC)
MBS2140230-01Recombinant p53 Upregulated Modulator Of Apoptosis (PUMA)
MBS6453358-01PUMA (p53 Upregulated Modulator of Apoptosis) (APC)

Popular Products