Hyp-dBET1

CAT: 0804-HY-173256Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-173256Size:1 Each
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Description
Hyp-dBET1 is a PROTAC degrader targeting BRD4. Hyp-dBET1 has an IC50 value of 3.4 μM in MDA-MB-231 cells. Hyp-dBET1 can be activated by hypoxia and recruit the E3 ubiquitin ligase and degrade BRD4 through ubiquitin-proteasome system. Hyp-dBET1 can be used for anti-tumor study[1].
UNSPSC
12352005
Target
Epigenetic Reader Domain; PROTACs
Related Pathways
Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
CC1=C(C)C(C(C2=CC=C(Cl)C=C2)=N[C@H]3CC(N(CC4=CC=C([N+]([O-])=O)C=C4)CCCCNC(COC5=C6C(C(N(C7C(NC(CC7)=O)=O)C6=O)=O)=CC=C5)=O)=O)=C(S1)N8C3=NN=C8C
Molecular Formula
C45H42ClN9O9S
Molecular Weight
920.39
References & Citations
[1]Dutta R, et al. Dual-Action-Only PROTACs. J Am Chem Soc. 2025 Mar 19;147 (11) :9074-9078.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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