DEALA-Hyp-YIPD

• Description:

  DEALA-Hyp-YIPD is an HIF-1α peptide that inhibits VHL/HIF-1α interaction with an IC50 of 0.91 μM and a Kd of 180 nM[1].

• UNSPSC:

  12352209

• Target:

  Others

• Type:

  Peptides

• Related Pathways:

  Others

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/deala-hyp-yipd.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(N[C@@H](CCC(O)=O)C(N[C@@H](C)C(N[C@@H](CC(C)C)C(N[C@@H](C)C(N1[C@@H](C[C@@H](O)C1)C(N[C@@H](CC2=CC=C(C=C2)O)C(N[C@@H]([C@@H](C)CC)C(N3[C@@H](CCC3)C(N[C@@H](CC(O)=O)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC(O)=O)N

• Molecular Formula:

  C50H74N10O19

• Molecular Weight:

  1119.18

• References & Citations:

  [1]Buckley DL, et al. Targeting the von Hippel-Lindau E3 ubiquitin ligase using small molecules to disrupt the VHL/HIF-1α interaction. J Am Chem Soc. 2012 Mar 14;134 (10) :4465-8.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Peptides

• Clinical Information:

  No Development Reported