Boc-Hyp-OH

CAT: 0804-HY-I0781-01Size: 5 gDry Ice: NoHazardous: No
CAT#:0804-HY-I0781-01Size:5 g
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Description
Boc-Hyp-OH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Boc-Hyp-OH is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[2]
CAS Number
[13726-69-7]
UNSPSC
12352203
Hazard Statement
H302, H315, H319, H335
Target
ADC Linker; PROTAC Linkers
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/boc-hyp-oh.html
Purity
99.95
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(C)(C)OC(N1[C@@H](C[C@H](C1)O)C(O)=O)=O
Molecular Formula
C10H17NO5
Molecular Weight
231.25
Precautions
H302, H315, H319, H335
References & Citations
[1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16 (5) :315-337.|[2]Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27 (8) :998-985.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Non-cleavable Linker

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Alternative Products

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5-04899Boc-Hyp-OH
5-04902Boc-Cis-Hyp-OH
A-2820.0001Boc-Hyp(Bzl)-OH
OR1012518-01Boc-Hyp (Bzl) -Oh
5-04944Boc-D-trans-Hyp-OH
5-04910Boc-Hyp(tBu)-OH·DCHA
5-04942Boc-D-Cis-Hyp-OH
5-04904Boc-Hyp-OMe
A-4535.0005Boc-Hyp-OBzl
A-4405.0005Boc-Hyp-OtBu

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