DAO-dBET1

• Description :

  DAO-dBET1 is a Dual-Action-Only PROTAC containing a PROTAC degrader, dBET1 (HY-101838) . DAO-dBET1 is a potent BRD4 degrader with a DC50 value of 277 nM in the presence of CoCl2. DAO-dBET1 inhibits hypoxia and Cath-L trigger with an IC50 value of 281 nM[1].

• UNSPSC :

  12352005

• Target :

  Epigenetic Reader Domain; PROTACs

• Related Pathways :

  Epigenetics; PROTAC

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Smiles :

  CC1=C(C)C(C(C2=CC=C(Cl)C=C2)=N[C@H]3CC(N(CC4=CC=C([N+]([O-])=O)C=C4)CCCCN(C(COC5=C6C(C(N(C7C(NC(CC7)=O)=O)C6=O)=O)=CC=C5)=O)CC8=CC=C(NC([C@@H](NC(OC(C)(C)C)=O)CCCCNC(C)=O)=O)C=C8)=O)=C(S1)N9C3=NN=C9C

• Molecular Formula :

  C65H71ClN12O13S

• Molecular Weight :

  1295.85

• References & Citations :

  [1]Ranit Dutta, et al. Dual-Action-Only PROTACs. J Am Chem Soc. 2025 Mar 19;147 (11) :9074-9078.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported