Cath-L-dBET1

• Description:

  Cath-L-dBET1 is a PROTAC degrader targeting BRD4. Cath-L-dBET1 has an IC50 value of 2.8 μM in MDA-MB-231 cells. Cath-L-dBET1 can be activated by cathepsin L (Cath-L) and recruit the E3 ubiquitin ligase and degrade BRD4 through ubiquitin-proteasome system. Hyp-dBET1 can be used for anti-tumor study[1].

• UNSPSC:

  12352005

• Target:

  Epigenetic Reader Domain; PROTACs

• Related Pathways:

  Epigenetics; PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Smiles:

  CC1=C(C)C(C(C2=CC=C(Cl)C=C2)=N[C@H]3CC(NCCCCN(C(COC4=C5C(C(N(C6C(NC(CC6)=O)=O)C5=O)=O)=CC=C4)=O)CC7=CC=C(NC([C@@H](NC(OC(C)(C)C)=O)CCCCNC(C)=O)=O)C=C7)=O)=C(S1)N8C3=NN=C8C

• Molecular Formula:

  C58H66ClN11O11S

• Molecular Weight:

  1160.73

• References & Citations:

  [1]Dutta R, et al. Dual-Action-Only PROTACs. J Am Chem Soc. 2025 Mar 19;147 (11) :9074-9078.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported