GI-Y2

• Description :

  GI-Y2 is an inhibitor of GSDMD and can inhibit Pyroptosis of macrophages induced by oxidized low-density lipoprotein (ox-LDL) . In vivo, GI-Y2 can dose-dependently reduce atherosclerotic plaques in ApoE-/- mice and decrease the lesion size and fibrosis degree of the aortic root. GI-Y2 is expected to be used in the research of pyroptosis and cardiovascular diseases, such as atherosclerosis[1].

• UNSPSC :

  12352005

• Target :

  Pyroptosis

• Related Pathways :

  Apoptosis; Immunology/Inflammation

• Field of Research :

  Cardiovascular Disease

• Smiles :

  OC(C1=CC=C(CN2C(SC(NC3=CC=C(C(O)=O)C=C3)C2=O)=O)C=C1)=O

• Molecular Formula :

  C18H14N2O6S

• Molecular Weight :

  386.38

• References & Citations :

  [1]Fan X, et al. The novel GSDMD inhibitor GI-Y2 exerts antipyroptotic effects to reduce atherosclerosis. Clin Transl Med. 2025 Mar;15 (3) :e70263.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1008710-58-4]