GI-Y2

• Target :

  Pyroptosis

• Related Pathways :

  Apoptosis|||Immunology/Inflammation

• Bioactivity :

  GI-Y2 is a GSDMD inhibitor that suppresses macrophage pyroptosis induced by oxidized low-density lipoprotein (ox-LDL) . In vivo, GI-Y2 dose-dependently reduces atherosclerotic plaques and decreases lesion size and fibrosis in the aortic root of ApoE-/- mice. GI-Y2 holds potential for research in pyroptosis and cardiovascular diseases, such as atherosclerosis.

• Smiles :

  O=C(O)C1=CC=C(C=C1)NC2SC(=O)N(C2=O)CC3=CC=C(C=C3)C(=O)O

• Molecular Formula :

  C18H14N2O6S

• Molecular Weight :

  386.379

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  1008710-58-4