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GI-Y2

CAT: 0931-T206350-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-T206350-01Size:10 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1008710-58-4
Target
Pyroptosis
Related Pathways
Apoptosis|||Immunology/Inflammation
Bioactivity
GI-Y2 is a GSDMD inhibitor that suppresses macrophage pyroptosis induced by oxidized low-density lipoprotein (ox-LDL) . In vivo, GI-Y2 dose-dependently reduces atherosclerotic plaques and decreases lesion size and fibrosis in the aortic root of ApoE-/- mice. GI-Y2 holds potential for research in pyroptosis and cardiovascular diseases, such as atherosclerosis.
Smiles
O=C(O)C1=CC=C(C=C1)NC2SC(=O)N(C2=O)CC3=CC=C(C=C3)C(=O)O
Molecular Formula
C18H14N2O6S
Molecular Weight
386.379
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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