α-Conotoxin GI

CAT: 0804-HY-137788Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-137788Size:5 mg
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CAS Number
[76862-65-2]
UNSPSC Description
α-Conotoxin GI has high affinity for nAChR.α-Conotoxin GI is a short peptide toxin that can be isolated from the venom of Conus geographus.α-Conotoxin GI has the similar activity with neuromuscular blocking agent[1][2][3].
Target Antigen
nAChR
Type
Peptides
Related Pathways
Membrane Transporter/Ion Channel;Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Solubility
10 mM in DMSO
Smiles
O=C([C@@H](N)CCC(O)=O)N[C@H](C(N[C@H](C(N[C@H](C(N1[C@H](C(N[C@H]2C)=O)CCC1)=O)CC(N)=O)=O)CSSC[C@H](NC3=O)C(N)=O)=O)CSSC[C@H](NC2=O)C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]3CO)=O)CC4=CC=C(O)C=C4)=O)CC5=CNC=N5)=O)CCCNC(N)=N)=O)=O
Molecular Weight
1437.61
References & Citations
[1]Groebe DR, et al. Determinants involved in the affinity of alpha-conotoxins GI and SI for the muscle subtype of nicotinic acetylcholine receptors. Biochemistry. 1997 May 27;36(21):6469-74.|[2]Yu S, et al. Sensitive Detection of α-Conotoxin GI in Human Plasma Using a Solid-Phase Extraction Column and LC-MS/MS. Toxins (Basel). 2017 Jul 28;9(8):235.|[3]Blount K, et al. alpha-Conotoxin GI produces tetanic fade at the rat neuromuscular junction. Toxicon. 1992 Aug;30(8):835-42.
Shipping Conditions
Room temperature
Clinical Information
No Development Reported

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