α-Conotoxin GI

• UNSPSC Description :

  α-Conotoxin GI has high affinity for nAChR.α-Conotoxin GI is a short peptide toxin that can be isolated from the venom of Conus geographus.α-Conotoxin GI has the similar activity with neuromuscular blocking agent[1][2][3].

• Target Antigen :

  nAChR

• Type :

  Peptides

• Related Pathways :

  Membrane Transporter/Ion Channel;Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C([C@@H](N)CCC(O)=O)N[C@H](C(N[C@H](C(N[C@H](C(N1[C@H](C(N[C@H]2C)=O)CCC1)=O)CC(N)=O)=O)CSSC[C@H](NC3=O)C(N)=O)=O)CSSC[C@H](NC2=O)C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]3CO)=O)CC4=CC=C(O)C=C4)=O)CC5=CNC=N5)=O)CCCNC(N)=N)=O)=O

• Molecular Weight :

  1437.61

• References & Citations :

  [1]Groebe DR, et al. Determinants involved in the affinity of alpha-conotoxins GI and SI for the muscle subtype of nicotinic acetylcholine receptors. Biochemistry. 1997 May 27;36(21):6469-74.|[2]Yu S, et al. Sensitive Detection of α-Conotoxin GI in Human Plasma Using a Solid-Phase Extraction Column and LC-MS/MS. Toxins (Basel). 2017 Jul 28;9(8):235.|[3]Blount K, et al. alpha-Conotoxin GI produces tetanic fade at the rat neuromuscular junction. Toxicon. 1992 Aug;30(8):835-42.

• Shipping Conditions :

  Room temperature

• Clinical Information :

  No Development Reported

• CAS Number :

  [76862-65-2]