GI-530159

CAT: 0804-HY-W013712-01Size: 1 gDry Ice: NoHazardous: No
CAT#:0804-HY-W013712-01Size:1 g
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GI-530159 is a selective opener of TREK1 and TREK2 potassium channels. GI-530159 displays selectivity for TREK1/2 over TRAAK, TASK3 and other potassium channels, with an EC50 of 0.76 μM for TREK1. GI-530159 reduces rat dorsal root ganglion neuron excitability and shows potential analgesic effect[1].
CAS Number
[69563-88-8]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/gi-530159.html
Concentration
10mM
Purity
99.72
Solubility
DMSO : ≥ 100 mg/mL
Smiles
FC(C(C1=CC=C(OC2=CC=C(N)C=C2)C=C1)(C3=CC=C(OC4=CC=C(N)C=C4)C=C3)C(F)(F)F)(F)F
Molecular Formula
C27H20F6N2O2
Molecular Weight
518.45
Precautions
H302, H315, H319, H335
References & Citations
[1]Loucif AJC, et al. GI-530159, a novel, selective, mechanosensitive two-pore-domain potassium (K2P) channel opener, reduces rat dorsal root ganglion neuron excitability. Br J Pharmacol. 2018;175 (12) :2272-2283.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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