GI-129471

• Description :

  GI-129471 is a MMP inhibitor. GI-129471 exhibits inhibitory activity against cancer cell invasion. GI-129471 can completely block the enhanced production of IgE and IgG1 by mouse B cells induced by rat mast cell protease-I (RMCP-I) . GI-129471 can be used for the study of cancer and mast cell chymase-regulated immunological processes[1][2].

• UNSPSC :

  12352005

• Target :

  MMP

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Cancer; Inflammation/Immunology

• Smiles :

  ONC([C@@H](CSC1=CC=CC=C1)[C@@H](CC(C)C)C(N[C@H](C(NC)=O)CC2=CC=CC=C2)=O)=O

• Molecular Formula :

  C25H33N3O4S

• Molecular Weight :

  471.61

• References & Citations :

  [1]Kempen I, et al. 3-Bromophenyl 6-acetoxymethyl-2-oxo-2H-1-benzopyran-3-carboxylate inhibits cancer cell invasion in vitro and tumour growth in vivo. Br J Cancer. 2003 Apr 7;88 (7) :1111-8. |[2]Yoshikawa T, et al. Rat mast cell protease-I enhances immunoglobulin E production by mouse B cells stimulated with interleukin-4. Immunology. 2001 Nov;104 (3) :333-40.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [130370-59-1]