RegisterLogin

DS-103

CAT: 0804-HY-173064Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-173064Size:1 Each
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
DS-103 is an inhibitor for HDAC that inhibits HDAC1, HDAC2, HDAC3, HDAC6 and HDAC8 with IC50s of 0.029, 0.123, 0.022, 0.367 and 9.26 μM, respectively. DS-103 inhibits Plasmodium falciparum 3D7 with IC50 of 5.08 μM. DS-103 exhibits cytotoxicity in cells A2780 and Cal27 with IC50 of 1.48 μM and 1.47 μM, reverses Cisplatin (HY-17394) resistance in A2780 and Cal27 with IC50 of 4.62 μM and 2.23 μM. DS-103 exhibits synergistic effect with Cisplatin (HY-17394), enhances Cisplatin-induced apoptosis[1].
UNSPSC
12352005
Target
HDAC; Parasite
Related Pathways
Anti-infection; Cell Cycle/DNA Damage; Epigenetics
Applications
COVID-19-anti-virus
Field of Research
Cancer; Infection
Smiles
O=C(N(CC1=CC=C(C=C1)C(NNCC)=O)CC(NCC2=CC=CC=C2)=O)C3=CC=C(C=C3)N(C)C
Molecular Formula
C28H33N5O3
Molecular Weight
487.59
References & Citations
[1]Stopper D, et al., Exploring Alternative Zinc-Binding Groups in Histone Deacetylase (HDAC) Inhibitors Uncovers DS-103 as a Potent Ethylhydrazide-Based HDAC Inhibitor with Chemosensitizing Properties. J Med Chem. 2025 Feb 27;68 (4) :4426-4452.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC1; HDAC2; HDAC3; HDAC6; HDAC8

Related Products

CatalogName
HY-163839DS-1093a
HY-P991577-01DS-8895
HY-152241-01DS-9300
HY-114217DS-003
HY-116880DS-2969b
HY-P991365DS-1501
HY-144401-01DS-3801b
HY-124131-01DS-437
HY-131182-01DS-1971a
HY-124581DS-6930

Alternative Products

CatalogName
T205596-01DS-103
C18240DS-1001b (DS 1001)
MBS3611038-01DS-1001b
MBS3612405-01DS-6051b
D4015DNA, ds
MBS3843764-01Ds-HAPP
T9685-01DS-1971a
T9901A-1690-01DS-1501
T89077-01DS-1093a
T36083-01DS-7423

Popular Products