DS-437

CAT: 0804-HY-124131-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-124131-01Size:5 mg
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Description
DS-437 is a dual PRMT5/7 inhibitor (IC50s of PRMT5/7=6 μM) . DS-437 is selective for PRMT5 and PRMT7 over 29 other human protein-, DNA-, and RNA-methyltransferases. DS-437 is a S-adenosylmethionine (SAM) -competitive inhibitor of PRMT5. DS-437 also inhibits DNMT3A and DNMT3B, with IC50s of 52 and 62 μM, respectively. DS-437 inhibits the methylation of FOXP3[1][2].
CAS Number
[1674364-87-4]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Histone Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ds-437.html
Purity
99.22
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O[C@@H]([C@H]([C@H](N1C=NC2=C(N=CN=C21)N)O3)O)[C@H]3CSCCNC(NCC)=O
Molecular Formula
C15H23N7O4S
Molecular Weight
397.45
Precautions
H302, H315, H319, H335
References & Citations
[1]Smil D, et al. Discovery of a Dual PRMT5-PRMT7 Inhibitor.ACS Med Chem Lett. 2015 Mar 2;6 (4) :408-12.|[2]Nagai Y, et al. PRMT5 Associates With the FOXP3 Homomer and When Disabled Enhances Targetedp185erbB2/neu Tumor Immunotherapy.Front Immunol. 2019 Feb 8;10:174.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PRMT5; PRMT7

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