DS-103

CAT: 0931-MF-0113959-01Size: 10 mgDry Ice: NoHazardous: No

CAT#:0931-MF-0113959-01Size:10 mg

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PRICE

AVAILABILITY: InStock

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

1 / 1

Target

Parasite|||HDAC

Related Pathways

Microbiology/Virology|||Chromatin/Epigenetic|||DNA Damage/DNA Repair

Bioactivity

DS-103 is an HDAC inhibitor that targets HDAC1, HDAC2, HDAC3, HDAC6, and HDAC8 with IC50 values of 0.029, 0.123, 0.022, 0.367, and 9.26 ?M, respectively. It also inhibits the malignant malaria parasite [Plasmodium falciparum 3D7] with an IC50 of 5.08 ?M. In A2780 and Cal27 cells, DS-103 exhibits cytotoxicity with IC50 values of 1.48 ?M and 1.47 ?M, respectively, and reverses cisplatin resistance in these cells with IC50 values of 4.62 ?M and 2.23 ?M. DS-103 acts synergistically with cisplatin, enhancing apoptosis induced by cisplatin.

Molecular Formula

C28H33N5O3

Molecular Weight

487.59

Shipping Conditions

Cool pack

Storage Temperature

-20°C

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DS-103

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