DS-1093a

CAT: 0804-HY-163839Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-163839Size:1 Each
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Description
DS-1093a is an orally active hypoxia-inducible factor prolyl hydroxylase (HIF-PHD) inhibitor, with an EC50 of 0.49 μM in Hep3B cell EPO production. DS-1093a can be used in the research of renal anemia[1].
UNSPSC
12352005
Target
HIF/HIF Prolyl-Hydroxylase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/ds-1093a.html
Smiles
CC1=NC(CC2CCN(CC2)C3=CC=C(C=C3)C4=CC=C(C=C4)C[C@@H](O)C)=NC(C(NCC(O)=O)=O)=C1O
Molecular Formula
C29H34N4O5
Molecular Weight
518.60
References & Citations
[1]Naoki Tanaka, et al. Discovery of DS-1093a: An oral hypoxia-inducible factor prolyl hydroxylase inhibitor for the treatment of renal anemia. Bioorg Med Chem Lett. 2024 Jul 15:111:129891.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1

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