DS-1093a

• Description:

  DS-1093a is an orally active hypoxia-inducible factor prolyl hydroxylase (HIF-PHD) inhibitor, with an EC50 of 0.49 μM in Hep3B cell EPO production. DS-1093a can be used in the research of renal anemia[1].

• UNSPSC:

  12352005

• Target:

  HIF/HIF Prolyl-Hydroxylase

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/ds-1093a.html

• Smiles:

  CC1=NC(CC2CCN(CC2)C3=CC=C(C=C3)C4=CC=C(C=C4)C[C@@H](O)C)=NC(C(NCC(O)=O)=O)=C1O

• Molecular Formula:

  C29H34N4O5

• Molecular Weight:

  518.60

• References & Citations:

  [1]Naoki Tanaka, et al. Discovery of DS-1093a: An oral hypoxia-inducible factor prolyl hydroxylase inhibitor for the treatment of renal anemia. Bioorg Med Chem Lett. 2024 Jul 15:111:129891.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 1