DS-9300

• UNSPSC Description:

  DS-9300 is a potent, orally active, selective EP300/CBP HAT inhibitor with an IC50 value of 28 nM. DS-9300 has anticancer activity and can be used in prostate cancer disease research[1].

• Target Antigen:

  Histone Acetyltransferase

• Type:

  Reference compound

• Related Pathways:

  Epigenetics

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/ds-9300.html

• Solubility:

  DMSO : ≥ 125 mg/mL

• Smiles:

  COC1=CC=C(C=C1)C2(CCC(F)(CC2)F)C(N3C[C@@H](C[C@@H]3C(NC4=NC5=C(NN=C5)C=C4)=O)F)=O

• Molecular Weight:

  501.50

• References & Citations:

  [1]Ryutaro Kanada, et al. Discovery of DS-9300: A Highly Potent, Selective, and Once-Daily Oral EP300/CBP Histone Acetyltransferase Inhibitor. J Med Chem. 2023 Jan 12;66(1):695-715.

• Shipping Conditions:

  Blue Ice

• Clinical Information:

  No Development Reported

• CAS Number:

  2259641-46-6