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RNA binder 1

CAT: 0804-HY-172902Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-172902Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
RNA binder 1 (Compound 4b) is a blood-brain permeable RNA binder. RNA binder 1 can selectively bind to the G-quadruplex structure of the G4C2 repeat sequence RNA of the C9orf72 gene. RNA binder 1 significantly reduces the levels of toxic polypeptides poly (GA) and poly (GP) produced by the G4C2 repeat sequence in amyotrophic lateral sclerosis (ALS) patient-derived cells. RNA binder 1 has no significant effect on the antisense polypeptide poly (PR), showing selectivity for sense RNA. RNA binder 1 can be used in the study of ALS and frontotemporal dementia (FTD) [1].
UNSPSC
12352211
Target
DNA/RNA Synthesis
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Neurological Disease
Smiles
NC(N/N=C/C1=CC=CC(C2=CC=C(S2)C3=CC=C(S3)C4=CC=CC(/C=N/NC(N)=N)=N4)=N1)=N
Molecular Formula
C22H20N10S2
Molecular Weight
488.59
References & Citations
[1]Maiocchi A, et al. Design, synthesis and characterization of aryl bis-guanyl hydrazones as RNA binders of C9orf72 G4C2 extended repeats. Eur J Med Chem. 2025 May 7;293:117736.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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