RNA binder 1

CAT: 0931-MF-0115326-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0115326-01Size:10 mg
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
DNA/RNA Synthesis
Related Pathways
Cell Cycle/Checkpoint|||DNA Damage/DNA Repair
Bioactivity
RNA binder 1 (Compound 4b) is an RNA-binding agent capable of crossing the blood-brain barrier. It selectively binds to the G-quadruplex structure of the G4C2 repeat sequence RNA of the C9orf72 gene. This compound significantly reduces levels of the toxic polypeptides poly (GA) and poly (GP) in cells derived from amyotrophic lateral sclerosis (ALS) patients, while it has no significant impact on the antisense polypeptide poly (PR), demonstrating selectivity for sense RNA. RNA binder 1 is useful for studying ALS and frontotemporal dementia (FTD) .
Molecular Formula
C22H20N10S2
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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