PUC-55

• Description :

  PUC-55 is a 5-HT6R antagonist with a Ki of 37.5 nM that induces neuronal autophagy by inhibiting the mTOR pathway. It holds potential for research in the field of neurological disorders[1].

• UNSPSC :

  12352005

• Target :

  5-HT Receptor

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Smiles :

  OC(C1=NN(S(=O)(C2=C3C=CC=CC3=CC=C2)=O)C4=C1C=CC=C4)CN5CCN(C6=CC=CC=C6OC)CC5

• Molecular Formula :

  C30H30N4O4S

• Molecular Weight :

  542.65

• References & Citations :

  [1]Alcaíno JM, et al. Novel 5-HTR modulators as mTOR-dependent neuronal autophagy inductors. Sci Rep. 2025 Mar 11;15 (1) :8380.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  5-HT6 Receptor