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HPK1-IN-55

CAT: 0804-HY-170365Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-170365Size:1 Each
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Description
HPK1-IN-55 (compound 19) is a selective and orally active hematopoietic progenitor kinase 1 (HPK1) inhibitor with an IC50 of 637-fold vs GCK-like kinase and >1022-fold vs LCK) . HPK1-IN-55 has anticancer effects[1].
CAS Number
3048537-58-9
UNSPSC
12352005
Target
MAP4K
Related Pathways
MAPK/ERK Pathway
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Smiles
COC1=CC(NC2=CC=C3C4(N(CC3=N2)C)CCN(CC4)C5COC5)=C(N=C1C6=C(C7=CC=C6)N=CN7C)C(N)=O
Molecular Formula
C30H34N8O3
Molecular Weight
554.64
References & Citations
[1]Peng J, et.al. Discovery of Pyridine-2-Carboxamides Derivatives as Potent and Selective HPK1 Inhibitors for the Treatment of Cancer. J Med Chem. 2024 Dec 12;67 (23) :21520-21544.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MAP4K1/HPK1

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