PUC-10

• Description:

  PUC-10 is a 5-HT6 receptor antagonist with a Ki of 14.6 nM and an IC50 of 32 nM. In silico predictions suggest that PUC-10 is orally active and can cross the blood-brain barrier. PUC-10 can induce autophagy in SH-SY5Y cells by inhibiting the mTOR pathway. PUC-10 can be used in the research of neurological disorders[1].

• UNSPSC:

  12352005

• Target:

  5-HT Receptor; Autophagy; mTOR

• Related Pathways:

  Autophagy; GPCR/G Protein; Neuronal Signaling; PI3K/Akt/mTOR

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Smiles:

  OC(C1=CN(S(=O)(C2=C3C=CC=CC3=CC=C2)=O)C4=C1C=CC=C4)CN5CCN(C6=CC=CC=C6OC)CC5

• Molecular Formula:

  C31H31N3O4S

• Molecular Weight:

  541.66

• References & Citations:

  [1]Alcaíno JM, et al. Novel 5-HT6R modulators as mTOR-dependent neuronal autophagy inductors. Sci Rep. 2025 Mar 11;15 (1) :8380.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  5-HT6 Receptor

• CAS Number:

  [2064126-76-5]