RegisterLogin

PUC-10

CAT: 0804-HY-172678Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-172678Size:1 Each
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
PUC-10 is a 5-HT6 receptor antagonist with a Ki of 14.6 nM and an IC50 of 32 nM. In silico predictions suggest that PUC-10 is orally active and can cross the blood-brain barrier. PUC-10 can induce autophagy in SH-SY5Y cells by inhibiting the mTOR pathway. PUC-10 can be used in the research of neurological disorders[1].
CAS Number
[2064126-76-5]
UNSPSC
12352005
Target
5-HT Receptor; Autophagy; mTOR
Related Pathways
Autophagy; GPCR/G Protein; Neuronal Signaling; PI3K/Akt/mTOR
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
OC(C1=CN(S(=O)(C2=C3C=CC=CC3=CC=C2)=O)C4=C1C=CC=C4)CN5CCN(C6=CC=CC=C6OC)CC5
Molecular Formula
C31H31N3O4S
Molecular Weight
541.66
References & Citations
[1]Alcaíno JM, et al. Novel 5-HT6R modulators as mTOR-dependent neuronal autophagy inductors. Sci Rep. 2025 Mar 11;15 (1) :8380.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT6 Receptor

Related Products

CatalogName
HY-172679PUC-55
HY-168281P6P-10,10
HY-13726710-Methyl-10-deazaaminopterin
HY-169268Aβ-IN-10
HY-W10823710- (Benzyloxy) -10-oxodecanoic acid
HY-W039458-0110- (tert-Butoxy) -10-oxodecanoic acid
HY-N880810-O-Coumaroyl-10-O-deacetylasperuloside
HY-W670564A(4S) -10-Nor-calamenen-10-one
HY-W65426210α-Methoxy-9,10-dihydrolysergol-d3
HY-156412DHFR-IN-10

Alternative Products

CatalogName
T206402-01PUC-10
PPL00065-2bPuc-PTEN
T206605-01PUC-55
ELKP405PUC-SPYNE173
PVT45035pUC-HCN1 Plasmid
PVT11196pUC-SPYNE Plasmid
PVTB00065-2bpuc-PTEN Plasmid
PVT11200pUC-SPYNE173 Plasmid
8200025PUC-19 DNA
MSD16pUC 19 DNA

Popular Products