Sulfonadyn-47

• Description:

  Sulfonadyn-47 is a GTP-competitive dynamin I (dynI) inhibitor that targets the active site in the GTPase domain of dynamin I, with IC50 values of 3.5 μM against dynI, 27.3 μM in clathrin-mediated endocytosis (CME) assays, and 12.3 μM in synaptic vesicle endocytosis (SVE) assays. Sulfonadyn-47 increases seizure threshold. Sulfonadyn-47 can be used the study for the seizure[1].

• UNSPSC:

  12352005

• Target:

  Dynamin; Ras

• Related Pathways:

  Cytoskeleton; GPCR/G Protein; MAPK/ERK Pathway

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Smiles:

  BrC1=CC=C (C=C1) /C=C/CNCCCNS (=O) (C2=C3C=CC=CC3=CC=C2) =O

• Molecular Formula:

  C22H23BrN2O2S

• Molecular Weight:

  459.40

• References & Citations:

  [1]Odell LR, et al. The sulfonadyns: a class of aryl sulfonamides inhibiting dynamin I GTPase and clathrin mediated endocytosis are anti-seizure in animal models. RSC Med Chem. 2023 Apr 26;14 (8) :1492-1511.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  3064686-59-2