IU1-47

• Description :

  IU1-47 is a potent and specific USP14 inhibitor with an IC50 of 0.6 μM. IU1-47 inhibits IsoT/USP5 with an IC50 of 20 μM. IU1-47 induces tau elimination in cultured neurons[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H315, H319, H320

• Target :

  Deubiquitinase

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage

• Applications :

  Neuroscience-Neurodegeneration

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/iu1-47.html

• Concentration :

  10mM

• Purity :

  99.68

• Solubility :

  DMSO : 16.67 mg/mL (ultrasonic)

• Smiles :

  CC1=CC(C(CN2CCCCC2)=O)=C(N1C3=CC=C(C=C3)Cl)C

• Molecular Formula :

  C19H23ClN2O

• Molecular Weight :

  330.85

• Precautions :

  H315, H319, H320

• References & Citations :

  [1]Boselli M, et al. An inhibitor of the proteasomal deubiquitinating enzyme USP14 induces tau elimination in cultured neurons. J Biol Chem. 2017 Nov 24;292 (47) :19209-19225.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [670270-31-2]