IU1-47

• Description:

  IU1-47 is a potent and specific USP14 inhibitor with an IC50 of 0.6 μM. IU1-47 inhibits IsoT/USP5 with an IC50 of 20 μM. IU1-47 induces tau elimination in cultured neurons[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H315, H319, H320

• Target:

  Deubiquitinase

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/iu1-47.html

• Concentration:

  10mM

• Purity:

  99.68

• Solubility:

  DMSO : 16.67 mg/mL (ultrasonic)

• Smiles:

  CC1=CC (C (CN2CCCCC2) =O) =C (N1C3=CC=C (C=C3) Cl) C

• Molecular Formula:

  C19H23ClN2O

• Molecular Weight:

  330.85

• Precautions:

  H315, H319, H320

• References & Citations:

  [1]Boselli M, et al. An inhibitor of the proteasomal deubiquitinating enzyme USP14 induces tau elimination in cultured neurons. J Biol Chem. 2017 Nov 24;292 (47) :19209-19225.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  670270-31-2