BDE 47

• Description :

  BDE 47 targets mitochondria, inhibits mitochondrial oxidative phosphorylation (OXPHOS), decreases mitochondrial membrane potential (MMP) and induces apoptosis in embryonic cell. BDE 47 induces the generation of ROS, and activates the JNK signaling pathway. BDE 47 exhibits embryonic developmental toxicity in zebrafish[1].

• CAS Number :

  [5436-43-1]

• UNSPSC :

  12352005

• Hazard Statement :

  H351, H360, H373, H410

• Target :

  Apoptosis; JNK; Oxidative Phosphorylation; Reactive Oxygen Species (ROS)

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer; Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/bde-47.html

• Purity :

  98.37

• Solubility :

  DMSO : 200 mg/mL (ultrasonic)

• Smiles :

  BrC1=CC=C(C(Br)=C1)OC2=CC=C(C=C2Br)Br

• Molecular Formula :

  C12H6Br4O

• Molecular Weight :

  485.79

• Precautions :

  H351, H360, H373, H410

• References & Citations :

  [1]Zhuang J, et al., BDE-47 induced apoptosis in zebrafish embryos through mitochondrial ROS-mediated JNK signaling. Chemosphere. 2020 Nov;258:127385.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported