PI3K-IN-47

CAT: 0931-T78853-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0931-T78853-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Target

PI3K

Related Pathways

PI3K/Akt/mTOR signaling

Bioactivity

PI3K-IN-47 (Compound 27) is a potent bivalent inhibitor targeting the phosphoinositide 3-kinases (PI3K) family, with IC50 values of 0.44 nM for PI3Kα, and 7.18 nM, 13.92 nM, and 22.83 nM for PI3Kβ, PI3Kγ, and PI3Kδ respectively. It induces G1 phase cell cycle arrest and exhibits anti-neoplastic properties by restraining colony formation and cell migration. Additionally, PI3K-IN-47 has demonstrated the ability to suppress tumor growth in HGC-27 xenograft mouse models [1].

Molecular Formula

C50H46F4N8O8S2

Molecular Weight

1027.07

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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