PI3K-IN-47

PI3K-IN-47

• UNSPSC Description: PI3K-IN-47 (Compound 27) is a bivalent PI3K inhibitor (IC50: 0.44 nM for PI3Kα, 7.18 nM, 13.92 nM, 22.83 nM for PI3Kβ, PI3Kγ, PI3Kδ). PI3K-IN-47 induces cell cycle arrest in G1 phase, inhibits colony formation and cell migration. PI3K-IN-47 inhibits tumor growth in HGC-27 xenograft mice[1].
• Target Antigen: PI3K
• Type: Reference compound
• Related Pathways: PI3K/Akt/mTOR
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/pi3k-in-47.html
• Solubility: 10 mM in DMSO
• Smiles: CC1=C2C=C(C3=CN=C(OC)C(NS(C4=CC=C(F)C=C4F)(=O)=O)=C3)C=C(OCCCCCCCCOC5=CC(C6=CN=C(OC)C(NS(C7=CC=C(F)C=C7F)(=O)=O)=C6)=CC8=C(C)N=CN=C58)C2=NC=N1
• Molecular Weight: 1027.07
• References & Citations: [1]Xia L, et al. Design, synthesis, and biological evaluation of novel bivalent PI3K inhibitors for the potential treatment of cancer. Bioorg Chem. 2023 Nov;140:106814.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported