SB-583355

• Description :

  SB-583355 (Compound 56) is a potent G2A antagonist. SB-583355 can be prepared by a Suzuki reaction between 4-methoxyphenyl boronic acid and 3-bromo-4-hydroxybenzoic acid following the conditions followed by an amide coupling reaction. SB-583355 blocks the activation of G2A mediated either by 9-HOPE or T-10148 in human G2A expressing CHO-K1 cells. SB-583355 can be studied in research for inflammation, myeloid leukemia, and neuropathic pain[1].

• CAS Number :

  [3040121-49-8]

• UNSPSC :

  12352005

• Target :

  G2A (GPR132)

• Related Pathways :

  GPCR/G Protein

• Field of Research :

  Inflammation/Immunology; Neurological Disease

• Smiles :

  OC1=CC=C(C(N[C@H](C(NC2CCCCC2)=O)CC3=CC=CC=C3)=O)C=C1C4=CC=C(C=C4)OC

• Molecular Formula :

  C29H32N2O4

• Molecular Weight :

  472.58

• References & Citations :

  [1]Victor Hernandez-Olmo, et al., Development of a Potent and Selective G2A (GPR132) Agonist. J. Med. Chem. 2024, 67, 13, 10567–10588.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported