SB-583355

• Description:

  SB-583355 (Compound 56) is a potent G2A antagonist. SB-583355 can be prepared by a Suzuki reaction between 4-methoxyphenyl boronic acid and 3-bromo-4-hydroxybenzoic acid following the conditions followed by an amide coupling reaction. SB-583355 blocks the activation of G2A mediated either by 9-HOPE or T-10148 in human G2A expressing CHO-K1 cells. SB-583355 can be studied in research for inflammation, myeloid leukemia, and neuropathic pain[1].

• UNSPSC:

  12352005

• Target:

  G2A (GPR132)

• Related Pathways:

  GPCR/G Protein

• Field of Research:

  Inflammation/Immunology; Neurological Disease

• Smiles:

  OC1=CC=C(C(N[C@H](C(NC2CCCCC2)=O)CC3=CC=CC=C3)=O)C=C1C4=CC=C(C=C4)OC

• Molecular Formula:

  C29H32N2O4

• Molecular Weight:

  472.58

• References & Citations:

  [1]Victor Hernandez-Olmo, et al., Development of a Potent and Selective G2A (GPR132) Agonist. J. Med. Chem. 2024, 67, 13, 10567–10588.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  3040121-49-8