NB-3

• Description :

  NB-3 is a nicotinamide adenine dinucleotide (NAD) hydrolase SARM1 inhibitor. NB-3 intercepts NAD hydrolysis and undergoes covalent conjugation with the reaction product adenosine diphosphate ribose (ADPR) . The resulting small-molecule ADPR adducts are highly potent and confer compelling neuroprotection in neurological injury[1].

• UNSPSC :

  12352005

• Target :

  Toll-like Receptor (TLR)

• Related Pathways :

  Immunology/Inflammation

• Field of Research :

  Neurological Disease

• Smiles :

  O=C(NCC(F)(F)F)N(C)[C@H](C1=CC=NC=C1)C

• Molecular Formula :

  C11H14F3N3O

• Molecular Weight :

  261.24

• References & Citations :

  [1]Bratkowski M, et al. Uncompetitive, adduct-forming SARM1 inhibitors are neuroprotective in preclinical models of nerve injury and disease. Neuron. 2022 Nov 16;110 (22) :3711-3726.e16.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported