PDdEC-NB

• Description:

  PDdEC-NB is a disulfide cleavable linker used for the antibody-drug conjugate (ADC) .

• UNSPSC:

  12352203

• Hazard Statement:

  H302-H315-H319-H335

• Target:

  ADC Linker

• Type:

  ADC Related

• Related Pathways:

  Antibody-drug Conjugate/ADC Related

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/pddec-nb.html

• Purity:

  97.63

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(OC1=CC=C([N+]([O-])=O)C=C1)OCC(SSC2=NC=CC=C2)(C)C

• Molecular Formula:

  C16H16N2O5S2

• Molecular Weight:

  380.44

• Precautions:

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

• References & Citations:

  [1]Flygare, John, et al. Anthracycline disulfide intermediates, antibody-​drug conjugates and methods.WO 2016040825 A1 20160317.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  ADC Related

• Clinical Information:

  No Development Reported

• Isoform:

  Cleavable Linker; Disulfide Cleavable Linker

• CAS Number:

  [1956318-90-3]