Products for Research Use Only
RegisterLogin

NB-598

CAT: 0804-HY-16343-01Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-16343-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
NB-598 is a potent and competitive inhibitor of squalene epoxidase (SE), and suppresses triglyceride biosynthesis through the farnesol pathway. NB-598 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
CAS Number
131060-14-5
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
COX
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/nb-598.html
Concentration
10mM
Purity
98.69
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
CCN(C/C=C/C#CC(C)(C)C)CC1=CC=CC(OCC2=CC(C3=CSC=C3)=CS2)=C1
Molecular Formula
C27H31NOS2
Molecular Weight
449.67
Precautions
H302, H315, H319, H335
References & Citations
[1]Xia F, et al. Inhibition of cholesterol biosynthesis impairs insulin secretion and voltage-gated calcium channel function in pancreatic beta-cells. Endocrinology. 2008 Oct;149 (10) :5136-45.|[2]Horie M, et al. Effects of NB-598, a potent squalene epoxidase inhibitor, on the apical membrane uptake of cholesterol and basolateral membrane secretion of lipids in Caco-2 cells. Biochem Pharmacol. 1993 Jul 20;46 (2) :297-305.|[3]Horie M, et al. An inhibitor of squalene epoxidase, NB-598, suppresses the secretion of cholesterol and triacylglycerol and simultaneously reduces apolipoprotein B in HepG2 cells. Biochim Biophys Acta. 1993 May 20;1168 (1) :45-51.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Citation 01
Adv Sci (Weinh) . 2023 Sep;10 (27) :e2206878.|Antioxidants (Basel) . 2024 Jun 13;13 (6) :722.|Arch Pharm (Weinheim) . 2025 Feb;358 (2) :e2400807.|Cancer Lett. 2025 May 23:217810.|Cancer Res. 2022 Sep 2;82 (17) :3032-3044.|Cell Chem Biol. 2021 Jun 17;28 (6) :866-875.e5.|Cell Metab. 2020 Apr 7;31 (4) :862-877.e14.|Genome Biol. 2016 Jun 29;17 (1) :140. |J Steroid Biochem Mol Biol. 2015 Aug;152:34-44.|Sci China Life Sci. 2022 Feb;65 (2) :341-361.|Cell Death Dis. 2021 May 13;12 (5) :482.|Cell Rep. 2020 Aug 4;32 (5) :107944.|Nat Chem Biol. 2016 Jul;12 (7) :497-503. |University of Toronto. Department of Medical Biophysics

Related Products

CatalogName
HY-163483ELQ-598
HY-19546-01BAY-598
HY-N3210Nb-Demethylechitamine
HY-126498-01PDEC-NB
HY-203012NB-7
HY-124322-01NB-360
HY-W347470ANb-Feruloyltryptamine
HY-171213NB-3
HY-11014NB-216
HY-126519-01PDdEC-NB

Alternative Products

CatalogName
A3645-200NB-598
S0338-100mgNB 598
A3647-5.1NB-598 Maleate
MBS3840902-01NB-598 hydrochloride
A14131-50NB-598 50mg

Popular Products