NB-598

• UNSPSC Description:

  NB-598 is a potent and competitive inhibitor of squalene epoxidase (SE), and suppresses triglyceride biosynthesis through the farnesol pathway. NB-598 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

• Target Antigen:

  Others

• Type:

  Reference compound

• Related Pathways:

  Others

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/nb-598.html

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  CCN(C/C=C/C#CC(C)(C)C)CC1=CC=CC(OCC2=CC(C3=CSC=C3)=CS2)=C1

• Molecular Weight:

  449.67

• References & Citations:

  [1]Xia F, et al. Inhibition of cholesterol biosynthesis impairs insulin secretion and voltage-gated calcium channel function in pancreatic beta-cells. Endocrinology. 2008 Oct;149(10):5136-45.|[2]Horie M, et al. Effects of NB-598, a potent squalene epoxidase inhibitor, on the apical membrane uptake of cholesterol and basolateral membrane secretion of lipids in Caco-2 cells. Biochem Pharmacol. 1993 Jul 20;46(2):297-305.|[3]Horie M, et al. An inhibitor of squalene epoxidase, NB-598, suppresses the secretion of cholesterol and triacylglycerol and simultaneously reduces apolipoprotein B in HepG2 cells. Biochim Biophys Acta. 1993 May 20;1168(1):45-51.Adv Sci (Weinh). 2023 Sep;10(27):e2206878.|Antioxidants (Basel). 2024 Jun 13;13(6):722.|Cancer Res. 2022 Sep 2;82(17):3032-3044.|Cell Chem Biol. 2021 Feb 16;S2451-9456(21)00051-9.|Cell Metab. 2020 Apr 7;31(4):862-877.e14.|Genome Biol. 2016 Jun 29;17(1):140. |J Steroid Biochem Mol Biol. 2015 Aug;152:34-44.|Sci China Life Sci. 2021 May 27;1-21.|Cell Death Dis. 2021 May 13;12(5):482.|Cell Rep. 2020 Aug 4;32(5):107944.|Nat Chem Biol. 2016 Jul;12(7):497-503. |University of Toronto. Department of Medical Biophysics

• Shipping Conditions:

  Blue Ice

• Clinical Information:

  No Development Reported

• CAS Number:

  131060-14-5