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A2AR modulator-1

CAT: 0804-HY-170948Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-170948Size:1 Each
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Description
A2AR modulator-1 (Compound 45) is a selective negative allosteric adenosine A2a receptor (A2aR) modulator with an IC50 value of 9 nM. A2AR modulator-1 reduces the affinity of endogenous adenosine for the receptor and inhibits cAMP signaling pathway activation. A2AR modulator-1 potently restores pCREB phosphorylation in CD4+ T cells, reversing immunosuppression in the tumor microenvironment, and shows potential to suppress tumor growth and metastasis in triple-negative breast cancer models[1].
CAS Number
3007566-23-3
UNSPSC
12352005
Target
Adenosine Receptor
Related Pathways
GPCR/G Protein
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
N#CC1=C(C2=CC=CC(C3=CC=CN=C3)=C2)C(C#N)=C(N4CCCCC4)N=C1N
Molecular Formula
C23H20N6
Molecular Weight
380.45
References & Citations
[1]Boujut M, et al. Discovery of the First Efficacious Adenosine 2A Receptor Negative Allosteric Modulators for High Adenosine Cancer Immunotherapies. J Med Chem. 2025 Feb 27;68 (4) :4059-4078.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Adenosine A2A receptor (A2AR)

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