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A2AR modulator-1

CAT: 0013-GTR19263140-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19263140-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
A2AR modulator-1 (Compound 45) is a selective negative allosteric modulator of the adenosine A2a receptor (A2aR), with an IC50 value of 9 nM. It reduces the affinity of endogenous adenosine for the receptor and inhibits the activation of the cAMP signaling pathway. A2AR modulator-1 effectively restores pCREB phosphorylation in CD4+ T cells, reverses immunosuppression in the tumor microenvironment, and shows potential in inhibiting tumor growth and metastasis in a triple-negative breast cancer model.
CAS Number
3007566-23-3
Field of Research
Neuroscience, Pharmacology & Drug Discovery
Smiles
N#CC1=C (N=C (C (C#N) =C1C=2C=CC=C (C2) C3=CN=CC=C3) N4CCCCC4) N
Molecular Formula
C23H20N6
Molecular Weight
380.45
Storage Conditions
-20°C
Notes
For research use only.

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