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CDK9/PARP-IN-1

CAT: 0804-HY-170942Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-170942Size:1 Each
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Description
CDK9/PARP-IN-1 (compound 37) is a CDK9/PARP inhibitor. CDK9/PARP-IN-1 inhibits CDK9 and PARP1 with IC50s of 118 and 107 nM, respectively. CDK9/PARP-IN-1 exhibits broad-spectrum antiproliferative effects across multiple cancer cell lines[1].
CAS Number
3032818-67-7
UNSPSC
12352005
Target
CDK; PARP
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Field of Research
Cancer
Smiles
O=C1NN=C(CC2=CC=C(F)C(C(N3CCN(CC4=CC(NC5=NC=NC(C6=CC=C(F)C=C6OCC)=C5)=NC=C4)CC3)=O)=C2)C7=C1C=CC=C7
Molecular Formula
C38H34F2N8O3
Molecular Weight
688.73
References & Citations
[1]Huang J, et al. Design, synthesis and biological evaluation of dual CDK9/PARP inhibitors for the treatment of cancer. Eur J Med Chem. 2025 Apr 5;287:117367.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK9; PARP1

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