PARP-1-IN-4

PARP-1-IN-4

• CAS Number: 684234-56-8
• UNSPSC Description: PARP-1-IN-4 is a PARP-1 inhibitor. PARP-1-IN-4 has inhibitory activity against PARP-1 with IC50 value of 302 μM. PARP-1-IN-4 can be used for the research of lung adenocarcinoma[1].
• Target Antigen: PARP
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage;Epigenetics
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/parp-1-in-4.html
• Solubility: DMSO : 7.69 mg/mL (ultrasonic;warming;adjust pH to 2 with HCl;heat to 60°C)
• Smiles: O=C(CN1N=C(C2=C(C1=O)C=CC=C2)C3=CC=C(Cl)C=C3)NC4=CC=C(C=C4)Cl
• Molecular Weight: 424.28
• References & Citations: [1]Almahli H, et al. Development of novel synthesized phthalazinone-based PARP-1 inhibitors with apoptosis inducing mechanism in lung cancer. Bioorg Chem. 2018;77:443-456.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported