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CDK9 degrader-1

CAT: 0013-GTR19257608-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19257608-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CDK9degrader-1 is a selective CDK9 degrader (DC50: 0.4073 μM) . It recruits ATG101 to initiate the autophagy-lysosome pathway and forms autophagosomes by recruiting LC3, which then fuse with lysosomes to degrade CDK9 and its partner protein, Cyclin T1 (DC50: 1.215 μM) . CDK9degrader-1 induces caspase 3-mediated apoptosis and exhibits antitumor activity in a mouse HCT116 xenograft model.
Field of Research
Cell Biology, Epigenetics & Chromatin
Smiles
ClC1=CC=CC (Cl) =C1C (NC2=CNN=C2C (NC3CCN (C (CCC (NC4=C (CCC5) C5=CC6=C4CCC6) =O) =O) CC3) =O) =O
Molecular Formula
C32H34Cl2N6O4
Molecular Weight
637.56
Storage Conditions
-20°C
Notes
For research use only.

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