PARP-1-IN-13

PARP-1-IN-13

• CAS Number: 2999661-74-2
• UNSPSC Description: PARP-1-IN-13 (Compound 19c) is a PARP-1 inhibitor (IC50: 26 nM). PARP-1-IN-13 inhibits DNA single-strand breakage repair and aggravates DNA double-strand breakage. PARP-1-IN-13 promotes the apoptosis of cancer cells through the mitochondrial apoptosis pathway[1].
• Target Antigen: PARP
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage;Epigenetics
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/parp-1-in-13.html
• Solubility: 10 mM in DMSO
• Smiles: O=C1NC(C2=CC=C(/C=N/NC(NCC)=S)C=C2)=NC3=C1OC4=C3C=CC=C4
• Molecular Weight: 391.45
• References & Citations: [1]Yuanjiang Wang, et al. Design, synthesis, and biological evaluation of a series of benzofuran[3,2-d]pyrimidine-4(3H)-one derivatives containing thiosemicarbazone analogs as novel PARP-1 inhibitors. Bioorganic Chemistry. Volume 139, October 2023, 106759.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported