PARP/HDAC-IN-1

PARP/HDAC-IN-1

• UNSPSC Description: PARP/HDAC-IN-1 (compound B102) is a potent dual inhibitor of PARP and HDAC. PARP/HDAC-IN-1 inhibits PARP1, PARP2 and HDAC1 with IC50s of 19.01, 2.13, 1690 nM, respectively[1].
• Target Antigen: HDAC; PARP
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage;Epigenetics
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/parp-hdac-in-1.html
• Solubility: 10 mM in DMSO
• Smiles: FC(C(C(N1CCN(CC1)CC2=CC=C(C=C2)/C=C/C(NC3=C(C=C(C=C3)F)N)=O)=O)=C4)=CC=C4CC5=NNC(C6=C5C=CC=C6)=O
• Molecular Weight: 634.67
• References & Citations: [1]Zhu Q, et al. Novel dual inhibitors of PARP and HDAC induce intratumoral STING-mediated antitumor immunity in triple-negative breast cancer. Cell Death Dis. 2024 Jan 5;15(1):10.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported